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An excessive production of caffeine-dependent gastric hydrochloric acid can affect the degree of absorption of concomitantly used drugs by degrading the drug, converting the drug substance into an insoluble form, and altering its dissolution rate

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Gene expression profiling studies, particularly the Broad Institute Connectivity Map analysis published by Pickart and colleagues, demonstrated that GHK-Cu modulates the expression of approximately 4,000 human genes, representing roughly 6% of the human genome

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